Significant weight loss, fat loss, and especially the loss of skeletal muscle where prevalent inflammatory activity is present can be seen in a large number of patients who at the time of diagnosis already had malignant tumors of the digestive system. This unfortunate sequence of events that leads to physical deterioration is known as cancer cachexia syndrome, often present with anorexia. Tumor cachexia affects the treatment process of patients, and frequency of complications, and it significantly impairs the quality of life. Standard nutritional support is not enough to prevent to physical deterioration caused by tumor induced anorexia and cachexia. During the last few years, the different approaches in treating tumor cachexia and anorexia, have questioned the relevance of certain drugs and nutritive supplements or their combinations. Particularly, topical application of eicosapentaenoic acid (EPA), β-hydroxy β-methyl butyrate (HMB), glutamine, branched chain amino acids (BCAA), antioxidants, vitamin D, as well as drugs such as glucocorticosteroids, megestrol acetate, NSAIDs (NSAIDs) and cannabinoids have been used in the treatment of cancer patients with the syndrome of tumor cachexia and anorexia.