After percutaneous coronary interventions (PCIs), such as the placement of a coronary artery stent , a . Agency for Healthcare Research and Quality guideline recommends that aspirin be taken indefinitely.  Frequently, aspirin is combined with an ADP receptor inhibitor , such as clopidogrel , prasugrel , or ticagrelor to prevent blood clots . This is called dual antiplatelet therapy (DAPT). United States and European Union guidelines disagree somewhat about how long, and for what indications this combined therapy should be continued after surgery. guidelines recommend DAPT for at least 12 months, while EU guidelines recommend DAPT for 6–12 months after a drug-eluting stent placement.  However, they agree that aspirin be continued indefinitely after DAPT is complete.
NSAIDs are not recommended during pregnancy, particularly during the third trimester . While NSAIDs as a class are not direct teratogens , they may cause premature closure of the fetal ductus arteriosus and kidney ADRs in the fetus. Additionally, they are linked with premature birth  and miscarriage .   Aspirin, however, is used together with heparin in pregnant women with antiphospholipid antibodies .  Additionally, indomethacin is used in pregnancy to treat polyhydramnios by reducing fetal urine production via inhibiting fetal kidney blood flow.
Aspirin overdose has potentially serious consequences, sometimes leading to significant morbidity and mortality. Patients with mild intoxication frequently have nausea and vomiting, abdominal pain, lethargy, tinnitus, and dizziness. More significant symptoms occur in more severe poisonings and include hyperthermia, tachypnea, respiratory alkalosis, metabolic acidosis, hyperkalemia, hypoglycemia, hallucinations, confusion, seizure, cerebral edema, and coma. The most common cause of death following an aspirin overdose is cardiopulmonary arrest usually due to pulmonary edema.