Chills or cold flashes with goose bumps (" cold turkey ") alternating with flushing (hot flashes), kicking movements of the legs ("kicking the habit"  ) and excessive sweating are also characteristic symptoms.  Severe pains in the bones and muscles of the back and extremities occur, as do muscle spasms. At any point during this process, a suitable narcotic can be administered that will dramatically reverse the withdrawal symptoms. Major withdrawal symptoms peak between 48 h and 96 h after the last dose and subside after about 8 to 12 days. Sudden withdrawal by heavily dependent users who are in poor health is very rarely fatal. Morphine withdrawal is considered less dangerous than alcohol, barbiturate, or benzodiazepine withdrawal.  
EMR has a % complete eradication rate in patients with Barrett’s esophagus without high-risk characteristics (submucosal invasion, poorly differentiated tumors, or evidence of lymphatic or vascular invasion). In patients who had high-risk characteristics, the reported rate was %. Recurrence rates for both cancer and high-grade dysplasia were % ( 17 ). A 90% sustained remission rate of Barrett’s esophagus-associated neoplasia and intestinal metaplasia was reported in Europe, which was achieved by the combination of initial EMR and subsequent circumferential radiofrequency ablation at least six weeks later ( 23 ). As for squamous cell cancers in Asia, in a meta-analysis, the reported en bloc resection rate was %, and the recurrence rate was % ( 17 ).